Medical Fluid Cassettes and Related Systems

A method of delivering a medical fluid delivery therapy, comprising:

• mating a disposable cassette with a panel of a console;
• the disposable cassette including a plurality of fluid circuits, each fluid circuit including a path being defined by one and more inlets and outlets in which a fluid flows, a pump chamber disposed between a first valve receiving member and a second valve receiving member along the path, the pump chamber including a flexible membrane and a rigid portion;
• the console including one or more actuators disposed between a first pinch valve and a second pinch valve, the one or more actuators configured to move between a resting position and an upstroke position with respect to the panel;
• wherein when the disposable cassette is mated with the panel, the actuator aligns with the flexible membrane pump chamber, and the corresponding first pinch valve and the second pinch valve align and interface with the respective first valve receiving member and the second valve receiving member;
• causing the first pinch valve to open and the second pinch valve to close to draw a fluid into one of the fluid circuits;
• and
• causing the first pinch valve to close and the second pinch valve to open and the corresponding actuator to contact the flexible membrane and to extend toward the rigid portion.

A disposable cassette configured to be mated with a console, comprising:

• a housing;
• a plurality of fluid circuits disposed within the housing, each of the plurality of fluid circuits includes a path being defined by one or more inlets and outlets disposed in the housing;
• each fluid circuit being configured for unidirectional fluid flow along the path and the fluid circuits include a blood circuit, an ultrafiltrate circuit, a replacement fluid circuit and a return circuit;
• each fluid circuit including a pump chamber disposed between a first valve receiving member and a second valve receiving member;
• and
• one or more of the fluid circuits including a pressure sensor configured to detect pressure within the one or more of the fluid circuits;
• and
• an electrical communication interface configured to transmit the pressure from the pressure sensor to a console system.