Microspheres Containing Decellularized Donor Tissue and Their Use in Fabricating Polymeric Structures
AssigneesUniversity of Cincinnati, Children's Hospital Medical Center
InventorsChia-Ying James Lin, Stacey Gruber, Patrick W. Whitlock, Paulomi Ghosh
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Abstract
Decellularized matrix microspheres comprising a polymeric material and a donor tissue are provided. Also disclosed are structures containing a plurality of decellularized matrix microspheres incorporating a first polymer and a donor tissue; and a second polymer, wherein the decellularized matrix microspheres and the second polymer are in the form of a filament. Methods of treating a tissue injury employing the matrix microspheres and structures described as well as their methods of manufacture are also provided.
Claims25
A decellularized matrix microsphere comprising a polymeric material and a donor tissue.
A structure comprising:
- a plurality of decellularized matrix microspheres comprising a first polymer and a donor tissue;
- and
- a second polymer,
- wherein the decellularized matrix microspheres and the second polymer are in the form of a filament.
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A method of manufacturing a filament, the method comprising:
- decellularizing a donor tissue;
- encapsulating the donor tissue in a first polymer to provide decellularized matrix microspheres;
- and
- co-extruding the decellularized matrix microspheres with a second polymer to provide the filament.
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Dependencies are inferred from the claim text.