Pleuromutilin derivatives for the treatment of diseases mediated by microbes

A compound of formula (I)

• wherein
• n is 0 to 4;
• m is 0 or 1 with the proviso that the sulphur atom and R3 are in vicinal position (if m=0 then R3 is in position 2′, and if m=1 then R3 is on position 1′);
• R is ethyl or vinyl;
• R1 is hydrogen or (C1-6)alkyl,
• R2 is hydrogen or
• (C3-6)cycloalkyl, or
• unsubstituted (C1-6)alkyl, or
• (C1-6)alkyl substituted by one or more of
• hydroxy;
• preferably one or two,
• methoxy,
• halogen,
• (C3-6)cycloalkyl, or
• R1 and R2 together with the nitrogen atom to which they are attached Colin a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatoms e.g. selected from N or O, or
• R1 is hydroxy and R2 is formyl;
• R3 is OH, OR4, a halogen atom, or
• with the proviso that R3 is bound to 2′R3 represents —O—(CH2)p—O— with p is 2 or 3;
• R4 is unsubstituted (C1-6)alkyl or (C3-6)cycloalkyl.