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US 2020/0277602 A1Published application
Methods and compositions to inhibit metastasis and to treat fibrosis and to enhance wound healing
AssigneeAlbert Einstein College of Medicine
InventorsDavid SHARP, Brian O'ROURKE
Life of this patent
Estimating the term…
Abstract
Methods and compositions are provided for inhibiting or treating metastasis based on discoveries regarding Kif19 and Cep192. Methods and compositions are provided for enhancing wound healing, treating fibrosis, reducing scarring and treating nerve pain.
Claims16
1-43. (canceled)
A nucleic acid molecule targeting a sequence selected from the group consisting of:
- SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, and SEQ ID NO:
- 4, that is from 19 to 56 nucleotides in length, a single strand or duplex, and comprises a sequence selected from the group consisting of:
- (SEQ ID NO:
- 5)
- 5′-GGAAGUAAGCUCAGGAUCUCAGCAG-3;
- (SEQ ID NO:
- 6)
- 5′-GUCCUUCAUUCGAGUCCUAUAGUCGUC-3′;
- (SEQ ID NO:
- 7)
- 5′-CACAUGAUGCCUGCUAGUU-3′;
- (SEQ ID NO:
- 8)
- 5′-GACACUUUCUUCAUGAGCA-3′;
- and
- (SEQ ID NO:
- 9)
- 5′-GGACUUAAGUGCUACUAGU-3,
- or a sequence fully complementary thereto.
19 more elements
Dependencies are inferred from the claim text.