Novel antibacterial compounds and methods of making and using same

A compound of formula I, or a salt or solvate thereof:

• wherein:
• R1 is aryl, wherein the aryl is substituted with 1-3 substituents independently selected from the group consisting of S(C1-C6 alkyl), OC(═O)(C1-C3 alkyl), and CX3, wherein X is I, Cl, Br, or F;
• R2 is selected from the group consisting of C1-C8 alkyl, C3-C8 cycloalkyl, allyl, propargyl, homopropargyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl, wherein each one of the alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl groups is optionally substituted with 1-3 substituents independently selected from the group consisting of C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, OH, O(C1-C6 alkyl), F, Cl, Br, I, NO2, —C(═O)H, —C(═O)OH, —C(═O)O(C1-C6 alkyl), —C(═O)NH2, —C(═O)NH(C1-C6 alkyl), and —C(═O)N(C1-C6 alkyl)(C1-C6 alkyl);
• R3 is selected from the group consisting of C3-C8 cycloalkyl, aryl, and heteroaryl, wherein each one of the cycloalkyl, aryl, and heteroaryl groups is optionally substituted with 1-3 substituents independently selected from the group consisting of C1-C6 alkyl, OH, O(C1-C6 alkyl), F, Cl, Br, I, NO2, —C(═O)H, —C(═O)OH, —C(═O)O(C1-C6 alkyl), —C(═O)NH2, —C(═O)NH(C1-C6 alkyl), and —C(═O)N(C1-C6 alkyl)(C1-C6 alkyl);
• R4 is selected from the group consisting of C1-C6 alkyl, C3-C8 cycloalkyl, arylalkyl and heteroarylalkyl, wherein each of the alkyl, cycloalkyl, arylalkyl, and heteroarylalkyl groups is optionally substituted with 1-3 substituents independently selected from the group consisting of C1-C6 alkyl, OH, O(C1-C6 alkyl), F, Cl, Br, I, NO2, —C(═O)H, —C(═O)OH, —C(═O)O(C1-C6 alkyl), —C(═O)NH2, —C(═O)NH(C1-C6 alkyl), and —C(═O)N(C1-C6 alkyl)(C1-C6 alkyl);
• and
• R5 is H or methyl;
• with the proviso that when R1 represents an aryl group substituted with CX3, at least two of R1, R2, R3, and R4 cannot represent cyclohexyl.