Modulation hypoxia associated with stroke
AssigneeOmniox, Inc.
InventorsNatacha Le Moan, Ana Krtolica, Philberta Leung, Stephen P.L. Cary
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Abstract
The invention provides H—NOX proteins for the delivery of oxygen to hypoxic tissue following stroke. H—NOX proteins extravasate into hypoxic penumbra associated with stroke and preferentially accumulate for sustained delivery of oxygen to the hypoxic tissue to ameliorate adverse affects of stroke related hypoxia. In some embodiments, the H—NOX comprises PEGylated H—NOX and non-PEGylated H—NOX.
Claims145
A method for treating stroke in an individual, the method comprising administering a therapeutically effective amount of an H—NOX to the individual, wherein the H—NOX comprises H—NOX covalently bound to polyethylene glycol (PEG) and H—NOX that is not covalently bound to polyethylene glycol.
A method for delivering oxygen to an individual following a stroke, the method comprising administering a therapeutically effective amount of an H—NOX to the individual, wherein N—NOX comprises H—NOX covalently bound to polyethylene glycol and H—NOX that is not covalently bound to PEG.
A method for treating a transient ischemic attack in an individual, the method comprising administering a therapeutically effective amount of H—NOX to the individual, wherein the H—NOX comprises H—NOX covalently bound to PEG and H—NOX that is not covalently bound to PEG.
A method for delivering oxygen to an individual following a transient ischemic attack, the method comprising administering a therapeutically effective amount of an H—NOX to the individual, wherein the H—NOX comprises H—NOX covalently bound to PEG and H—NOX that is not covalently bound to PEG.
A method for treating a hypoxic brain injury in an individual, the method comprising administering a therapeutically effective amount of an H—NOX to the individual, wherein the H—NOX comprises H—NOX covalently bound to PEG and H—NOX that is not covalently bound to PEG.
A method for delivering oxygen to an individual following a hypoxic brain injury, the method comprising administering a therapeutically effective amount of an H—NOX to the individual, wherein the H—NOX comprises H—NOX covalently bound to PEG and H—NOX that is not covalently bound to PEG.
A composition comprising a therapeutically effective amount of an H—NOX, wherein the H—NOX comprises H—NOX covalently bound to polyethylene glycol (PEG) and H—NOX that is not covalently bound to polyethylene glycol.
A kit comprising a therapeutically effective amount of an H—NOX covalently bound to polyethylene glycol (PEG) and a therapeutically effective amount of an H—NOX that is not covalently bound to polyethylene glycol.
A method for preparing a composition for treating stroke, transient ischemic attack or hypoxic brain injury, the method comprising mixing an H—NOX covalently bound with PEG with an H—NOX that is not covalently bound to PEG.
Dependencies are inferred from the claim text.