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US 2020/0270705 A1Published application
Targeted cell free nucleic acid analysis
AssigneeNantHealth Labs, Inc.
InventorShahrooz Rabizadeh
Life of this patent
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Abstract
Methods of isolating cell free RNA from individual's bodily fluid and reliably obtain cell free RNA data are presented, preferably by use of high-stability portions and/or use of targeted small amplicons on the cell free RNA.
Claims22
A method of obtaining cell free RNA data, comprising:
- obtaining a sample containing cell free RNA from an individual;
- and
- amplifying a high-stability portion of the cell free RNA to obtain the cell free RNA data, wherein the cell free RNA data comprises at least one of RNA sequence data and RNA expression level.
3-18. (canceled)
A method of isolating cell free RNA, comprising:
- obtaining a sample containing cell free RNA from an individual;
- contacting the sample with a synthetic nucleic acid, wherein the synthetic nucleic acid is configured to bind to at least a portion of 5′-portion of the cell free RNA and form a cell free RNA-synthetic nucleic acid complex;
- and
- isolating the cell free RNA-synthetic nucleic acid complex.
1 more element
37-66. (canceled)
Dependencies are inferred from the claim text.