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AssigneeProcella Therapeutics AB
InventorsChuen Yan LEUNG, Jonathan CLARKE, Jiejia XU, Federica SANTORO, Makoto SAHARA, Kenneth R. CHIEN
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The present invention provides genetic markers for identifying engraftable human cardiac ventricular progenitor cells. The engraftment markers of the invention include angiogenic markers and extracellular matrix markers. Human ventricular progenitor cells expressing these markers are capable of forming ventricular tissue in vivo that is vascularized and supported by an extracellular matrix. Methods of engrafting human cardiac ventricular progenitor cells by transplanting into a subject progenitor cells that express the engraftment markers are also provided.
-5. (canceled)
The method of claim 31, wherein the at least one engraftment marker detected is at least one positive angiogenic marker.
The method of claim 31, wherein the at least one engraftment marker detected is at least one positive extracellular matrix marker.
The method of claim 31, wherein the at least one engraftment marker detected is at least one positive angiogenic marker and at least one positive extracellular matrix marker.
-15. (canceled)
-18. (canceled)
-21. (canceled)
The method of claim 31, wherein the at least one engraftment marker detected is at least one negative angiogenic marker.
The method of claim 31, wherein the at least one engraftment marker detected is at least one negative extracellular matrix marker.
The method of claim 31, wherein the at least one engraftment marker detected is at least one negative angiogenic marker and at least one negative extracellular matrix marker.
(canceled)
The method of claim 31, wherein detecting expression of at least one engraftment marker comprises detecting expression of mRNA encoding the at least one engraftment marker in the HVPs.
The method of claim 31, wherein detecting expression of at least one engraftment marker comprises detecting lack of expression of mRNA encoding the at least one engraftment marker in the HVPs.
A method of identifying engraftable human ventricular progenitor cells (HVPs), the method comprising:
Dependencies are inferred from the claim text.