Transcriptome transfer produces cellular phenotype conversion
AssigneeThe Trustees of the University of Pennsylvania
InventorsJames Eberwine, Jai-Yoon Sul, Chia-Wen Wu, Fanyi Zeng, Junhyong Kim
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Abstract
The present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a phenotype conversion in the transfected cell. Preferably the phenotype-converting nucleic acid is a transcriptome, and more preferably an mRNA transcriptome.
Claims23
A method of effecting phenotype conversion in a cell, said method comprising transfecting phenotype-converting nucleic acid of a first cell having a phenotype into a second cell having a phenotype, wherein the phenotype of said first cell is different from the phenotype of said second cell, and wherein said transfected phenotype-converting nucleic acid causes the phenotype of said second cell to change to the phenotype of said first cell.
23-26. (canceled)
Dependencies are inferred from the claim text.