Modifying the specificity of non-coding rna molecules for silencing gene expression in eukaryotic cells

A method of modifying a gene encoding or processed into an RNA silencing molecule to a target RNA in a eukaryotic cell, with the proviso that said eukaryotic cell is not a plant cell, the method comprising introducing into the eukaryotic cell a DNA editing agent which redirects a silencing specificity of said RNA silencing molecule towards a second target RNA, said target RNA and said second target RNA being distinct, thereby modifying the gene encoding the RNA silencing molecule.

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A method of modifying a gene encoding or processed into a non-coding RNA molecule having no RNA silencing activity in a eukaryotic cell, with the proviso that said eukaryotic cell is not a plant cell, the method comprising introducing into the eukaryotic cell a DNA editing agent conferring a silencing specificity of said non-coding RNA molecule towards a target RNA of interest, thereby modifying the gene encoding or processed into the non-coding RNA molecule.