Igf-1r antibody-drug-conjugate and its use for the treatment of cancer

An antibody-drug-conjugate of the following formula (I):

• Ab-(L-D)n (I)
• or a pharmaceutically acceptable salt thereof,
• wherein
• Ab is an antibody, or an antigen binding fragment thereof, capable of binding to the human IGF-1R selected from the group consisting of:
• (i) an antibody having a heavy chain variable domain of sequence SEQ ID No. 56 and a light chain variable domain of sequence SEQ ID No. 57;
• (ii) an antibody having a heavy chain variable domain of sequence SEQ ID No. 56 and a light chain variable domain of sequence SEQ ID No. 60;
• (iii) an antibody having a heavy chain variable domain of sequence SEQ ID No. 62 and a light chain variable domain of sequence SEQ ID No. 57;
• (iv) an antibody having a heavy chain variable domain of sequence SEQ ID No. 64 and a light chain variable domain of sequence SEQ ID No. 57;
• (v) an antibody having a heavy chain variable domain of sequence SEQ ID No. 64 and a light chain variable domain of sequence SEQ ID No. 60;
• (vi) an antibody having a heavy chain variable domain of sequence SEQ ID No. 66 and a light chain variable domain of sequence SEQ ID No. 57;
• (vii) an antibody having a heavy chain variable domain of sequence SEQ ID No. 68 and a light chain variable domain of sequence SEQ ID No. 57;
• (viii) an antibody having a heavy chain variable domain of sequence SEQ ID No. 68 and a light chain variable domain of sequence SEQ ID No. 60;
• (ix) an antibody having a heavy chain variable domain of sequence SEQ ID No. 70 and a light chain variable domain of sequence SEQ ID No. 57;
• (x) an antibody having a heavy chain variable domain of sequence SEQ ID No. 72 and a light chain variable domain of sequence SEQ ID No. 57;
• (xi) an antibody having a heavy chain variable domain of sequence SEQ ID No. 74 and a light chain variable domain of sequence SEQ ID No. 57;
• (xii) an antibody having a heavy chain variable domain of sequence SEQ ID No. 76 and a light chain variable domain of sequence SEQ ID No. 57;
• (xiii) an antibody having a heavy chain variable domain of sequence SEQ ID No. 78 and a light chain variable domain of sequence SEQ ID No. 57;
• (xiv) an antibody having a heavy chain variable domain of sequence SEQ ID No. 78 and a light chain variable domain of sequence SEQ ID No. 60;
• and
• (xv) an antibody having a heavy chain variable domain of sequence SEQ ID No. 80 and a light chain variable domain of sequence SEQ ID No. 57;
• L is a linker;
• D is a drug moiety of the following formula (II):
• wherein:
• R2 is COOH, COOCH3 or thiazolyl;
• R3 is H or (C1-C6)alkyl;
• R9 is H or (C1-C6)alkyl;
• m is an integer comprised between 1 and 8;
• the wavy line indicates the point of attachment to L;
• and
• n is 1 to 12.