Compositions and Methods for Treating Cancer
AssigneesThe Trustees of the University of Pennsylvania, Fondazione Irccs Istituto Nazionale Dei Tumori
InventorsDaniel J. Powell, George Coukos, Mariangela Figini, Silvana Canevari
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Abstract
The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having α-folate receptor (FRα) binding domain and 4-1BB (CD137) costimulatory domain to treat ovarian cancer.
Claims25
A cell comprising a nucleic acid sequence encoding a chimeric antigen receptor (CAR), wherein the nucleic acid sequence comprises a sequence encoding an α-folate receptor (FRα) antibody comprising the amino acid sequence of SEQ ID NO:
- 23.
A cell comprising a chimeric antigen receptor (CAR), wherein the CAR comprises an anti-folate receptor (FR α) antibody comprising the amino acid sequence of SEQ ID NO:
- 23.
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Dependencies are inferred from the claim text.