Treatment of kidney injury
AssigneesSingapore Health Services Pte Ltd, National University of Singapore
InventorsStuart Alexander Cook, Sebastian Schaefer, Anissa Anindya Widjaja
Life of this patent
Estimating the term…
Abstract
Methods of treating and preventing kidney injury through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.
Claims33
A method of treating, preventing or reversing kidney injury, the method comprising administering a therapeutically or prophylactically effective amount of an agent capable of inhibiting interleukin 11 (IL-11)-mediated signalling to a subject.
A method of improving renal function in a subject suffering from an impairment to renal function, the method comprising administering a therapeutically or prophylactically effective amount of an agent capable of inhibiting interleukin 11 (IL-11)-mediated signalling to a subject.
A method of promoting the proliferation, survival and/or function of tubular epithelial cells (TECs), and/or the growth, maintenance and/or function of renal tissue, the method comprising administering a therapeutically or prophylactically effective amount of an agent capable of inhibiting interleukin 11 (IL-11)-mediated signalling to a subject.
A method of inhibiting SNAIL expression, the method comprising administering a therapeutically or prophylactically effective amount of an agent capable of inhibiting interleukin 11 (IL-11)-mediated signalling to a subject.
A method of inhibiting or reversing the transition of tubular epithelial cells (TECs) to a mesenchymal cell-like phenotype, the method comprising administering a therapeutically or prophylactically effective amount of an agent capable of inhibiting interleukin 11 (IL-11)-mediated signalling to a subject.
Dependencies are inferred from the claim text.