Antibodies that specifically bind to human il-15 and uses thereof
AssigneeCephalon, Inc.
InventorsDavid Jose Simon LAINE, Matthew POLLARD, Anthony Gerard DOYLE, Lynn Dorothy POULTON, Adam William CLARKE
Life of this patent
Estimating the term…
Abstract
Recombinant antibodies that specifically bind to IL-15 as well as a complex of IL-15 and the IL-15 Receptor-alpha are provided. The antibodies inhibit immune cell proliferation, and are capable of use in the treatment of any autoimmune or inflammatory disease or condition where IL-15 is dysregulated, including Celiac disease.
Claims46
An antibody, comprising a variable heavy chain and a variable light chain, wherein the antibody specifically binds to an epitope comprising the S7, Q108, and N112 residues of human IL-15, wherein the IL-15 is complexed with IL-15 Receptor alpha (IL-15Rα).
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An antibody, comprising an HCDR1 comprising the amino acid sequence of SEQ ID NO:
- 16, an HCDR2 comprising the amino acid sequence of SEQ ID NO:
- 17, an HCDR3 comprising the amino acid sequence of SEQ ID NO:
- 20, an LCDR1 comprising the amino acid sequence of SEQ ID NO:
- 25, an LCDR2 comprising the amino acid sequence of SEQ ID NO:
- 28, and an LCDR3 comprising the amino acid sequence of SEQ ID NO:
- 29, wherein the antibody specifically binds to human IL-15, wherein the IL-15 is complexed with IL-15 Receptor alpha (IL-15Rα).
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An antibody that specifically binds to human IL-15, wherein the IL-15 is complexed with IL-15 Receptor alpha (IL-15Rα) wherein the antibody comprises
- (a) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:4 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:8;
- (b) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:4 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:503;
- (c) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:4 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:505;
- (d) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:4 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:507;
- (e) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:4 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:509;
- (f) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:4 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:510;
- (g) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:454 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:455;
- (h) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:454 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:503;
- (i) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:454 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:457;
- (j) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:454 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:505;
- (k) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:454 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:506;
- (l) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:454 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:507;
- (m) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:454 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:5;
- (n) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:454 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:509;
- or
- (o) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:454 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:510.
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-48. (canceled)
An antibody that binds to IL-15 wherein the IL-15 is complexed with IL-15 Receptor alpha (IL-15Rα), comprising a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises the amino acid sequence of SEQ ID NO:
- 4 and/or wherein the light chain variable region comprises the amino acid sequence of SEQ ID NO:
- 5.
-54. (canceled)
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-73. (canceled)
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-88. (canceled)
A polynucleotide comprising a nucleic acid sequence encoding an antibody variable heavy chain comprising the amino acid sequence of SEQ ID NO:
- 1 or an antibody variable light chain comprising the amino acid sequence of SEQ ID NO:2.
-95. (canceled)
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Dependencies are inferred from the claim text.