Pegylated endostatin analogue and application thereof
AssigneeBeijing Protgen Ltd.
InventorsDaifu Zhou, Wenchao Wang, Hui Li, Guodong Chang
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Abstract
The present invention provides a polyethylene glycol-modified endostatin analogue and an application thereof. The endostatin analogue is coupled to polyethylene glycol at lysine away from a nucleolin binding domain, or is coupled to polyethylene glycol at lysine away from a nucleolin binding domain and amidogen at the N end.
Claims25
An endostatin analogue-PEG coupled complex, wherein the endostatin analogue has a lysine residue at a position corresponding to position 96 of the amino acid sequence SEQ ID NO. 1 of naturally occurring endostatin, and no lysine residue at any other position;
- and the endostatin analogue is coupled to PEG only at the lysine residue or is coupled to PEG at N-terminus and the lysine residue.
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Dependencies are inferred from the claim text.