Method for extending half-life of protein
AssigneeUbiprotein, Corp.
InventorsKwang-Hyun BAEK, Kyunggon KIM, Myung-Sun KIM, Hyeonmi KIM, Su Kyung OH, Mi Jeong LEE, Sung-ryul BAE
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Abstract
The present invention relates to a method for prolonging the half-life of a protein, the method comprising substituting at least one lysine residue present in the amino acid sequence of the protein, and to a protein having an extended half-life. The protein of the present invention, in which the lysine residue has been substituted, remains in the human body for a long time and exhibits an excellent therapeutic effect. The protein of the present invention includes EGF, PDGFA and PDGFB, GM-CSF, FSH-alpha and FSH-beta, and ANGPT-1.
Claims31
A method for prolonging the half-life of a protein or (poly)peptide, comprising:
- substituting at least one lysine, which binds to the C-terminal glycine of ubiquitin, with arginine in the protein or (poly)peptide.
A protein with an extended half-life, wherein at least one of the lysine residues of the protein is substituted with arginine, and the lysine residue to be substituted binds to the C-terminal glycine of ubiquitin.
Dependencies are inferred from the claim text.