Tetrahydroisoquinoline derivatives

A method for treating a disease or condition selected from the group consisting of amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), myasthenia gravis, muscular myopathies, peripheral vascular disease, peripheral arterial disease, rehabilitation-related deficits, metabolic syndrome, obesity, ventilator-induced muscle weakness, and chronic fatigue syndrome, comprising administering to a subject in need thereof a compound of formula (I) or a salt thereof:

• wherein,
• X1 is C—R11 or N;
• X2is C—R12 or N;
• R11 is i) H, ii) halogen, iii) —CN, or iv) —O—C1-6 alkyl;
• R12 is H or halogen;
• R1 is i) H, ii) C1-6 alkyl which may be substituted with one or more substituent(s) selected from the group consisting of halogen(s), and pyrazolyl(s), iii) C2-6 alkenyl, or iv)
• —OR0;
• R2 is i) C1-6 alkyl which may be substituted with one or more substituent(s) selected from the group consisting of —OR0(s), halogen(s), —COOR0(s), —CONR21R22(s), phenyl(s) which may be substituted with one or more substituent(s) selected from the G1 group, and heteroaryl(s) which is selected from the group consisting of pyridyl, pyrazolyl, imidazolyl, thiazolyl, thiadiazolyl, thienyl, oxazolyl, isoxazolyl, and triazolyl, wherein, the heteroaryl may be substituted with one or more substituent(s) selected from the G2 group, ii) C2-6 alkenyl, iii) C2-6 alkynyl, iv) —OR0, v) —NR23R24, vi) —COOR0, or vii) phenyl;
• R21 is H or C1-6 alkyl;
• R22 is i) C1-6 alkyl which may be substituted with one or more phenyl(s), or ii) phenyl;
• R23 is i) H, or ii) C1-6 alkyl which may be substituted with one or more —OH(s);
• R24 is i) C1-6 alkyl which may be substituted with one or more phenyl(s) which may be substituted with one or more halogen(s), ii) C3-8 cycloalkyl which may be substituted with one or more C1-6 alkyl(s), iii) phenyl which may be substituted with one or more halogen(s), or iv) tetrahydropyranyl;
• or
• R1, R2, and a carbon atom bounded by R1 and R2 may interact to form a 4-piperidine ring or 4-tetrahydropyran ring, and the carbon atom bounded by R1 and R2 is a spiro atom and the 4-piperidine ring may be substituted with one or more substituent(s) selected from the group consisting of —SO2—(C1-6 alkyl) and —COOR0;
• R3 and R4 are the same or different each other, i) C1-3 alkyl which may be substituted with one or more substituent(s) selected from the group consisting of halogen(s) and —OH(s) or ii) C2-6 alkenyl which may be substituted with one or more substituent(s) selected from the group consisting of —OH(s) and heteroaryl(s) which is selected from the group consisting of pyrazolyl and thienyl, wherein the heteroaryl may be substituted with one or more C1-6 alkyl(s), or,
• R3, R4, and a carbon atom bounded by R3 and R4 may interact to form a 3-oxetane ring and the carbon atom bounded by R3 and R4 is a spiro atom;
• R5 is i) H, ii) C1-6 alkyl which may be substituted with one or more —O—(C1-6 alkyl)(s), iii) —O—C1-6 alkyl, iv) halogen, v) —COO—(C1-6 alkyl), or vi) C3-8 cycloalkyl;
• R6 is i) H, ii) C1-6 alkyl which may be substituted with one or more substituent(s) selected from the group consisting of —O—(C1-6 alkyl(s) which may be substituted with one or more halogen(s)) and halogen(s), iii) —OH, iv) —O—(C1-6 alkyl which may be substituted with one or more halogen(s)), v) halogen, vi) —CN, vii) —S—(C1-6 alkyl), viii) C3-8 cycloalkyl, ix) —NR0R0, or x) C2-6 alkenyl;
• G1 group is i) halogen, ii) —COOR0, iii) —CONR0R0, iv) —OH, v) C1-6 alkyl which may be substituted with one or more substituent(s) selected from the group consisting of —OH(s) and halogen, or vi) —O—(C1-6 alkyl which may be substituted with one or more substituent(s) selected from the group consisting of —OH(s) and halogen(s));
• G2 group is i) halogen, ii) C1-6 alkyl which may be substituted with one or more substituent(s) selected from the group consisting of —OH(s) and halogen(s) or iii) —CONR0R0,
• each R0 is the same or different each other, H or C1-6 alkyl,
• provided that said compound is not methyl 1,1-diallyl-3-oxo-2,4-dihydroisoquinoline-4-carboxylate or a salt thereof.