Solid forms of ttk inhibitor
AssigneeUniversity Health Network
InventorsSze-Wan Li, Heinz W. Pauls, Peter Brent Sampson
Life of this patent
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Abstract
The present invention relates to a novel co-crystal of the compound of formula (I): wherein the co-former molecule is bisphosphate hemihydrate, to processes for the preparation of the co-crystal, to pharmaceutical compositions containing the co-crystal, to the use of such a co-crystal in the manufacture of a medicament for use in the treatment of cancer and to methods of treating such diseases in the human or animal body by administering a therapeutically effective amount of such a co-crystal.
Claims22
1-59. (canceled)
A method of treating a subject with cancer, comprising administering to the subject an effective amount of a co-crystal of compound (I) and a co-former molecule,
- or a solvate of the co-crystal, wherein the co-former molecule is phosphoric acid.
A method of treating a subject with cancer, comprising administering to the subject an effective amount of a hydrobromide salt of compound (I) represented by the following structure formula:
- or a solvate thereof, wherein the molar ratio between compound (I) and hydrobromic acid is 1:1, wherein the hydrobromide salt is crystalline, and the crystalline hydrobromide salt is characterized by any three, four, five, six, seven, or eight of X-ray powder diffraction pattern peaks at 5.90, 10.00, 11.9°, 13.8°, 17.3°, 19.4°, 21.3°, 21.6°, and 22.0°±0.2 in 2θ.
Dependencies are inferred from the claim text.