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US 2020/0270239 A1Published application
Compounds, salts thereof and methods for treatment of diseases
AssigneeACADIA Pharmaceuticals Inc.
InventorsEthan S. BURSTEIN, Roger OLSSON, Björn Gustav BORGSTRÖM, Karl Erik JANSSON, Niklas Patrik SKÖLD, Henrik VON WACHENFELDT, Larisa Yudina WAHLSTRÖM
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to compounds according to Formula (I), useful for treating diseases.
Claims35
A compound according to Formula (I)
- or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or deuterated analogue thereof, wherein:
- m, and n are independently an integer selected from the group consisting of 0, 1, 2, and 3;
- p, and q are independently an integer selected from the group consisting of 0, 1, 2, 3, and 4;
- R1 and R1d are fluoro;
- R1a, R1b, and R1c are hydrogen;
- R2, R2a, R2b, R2c and R2d are independently selected from the group consisting of hydrogen, deuterium, amino, hydroxyl, —OD, halogen, cyano, nitro, unsubstituted or substituted C1-6 alkyl, unsubstituted or substituted C1-6 haloalkyl, unsubstituted or substituted C1-6 hydroxyalkyl, unsubstituted or substituted C2-6 alkenyl, unsubstituted or substituted C2-6 alkenyloxy, unsubstituted or substituted C2-6 alkynyl, unsubstituted or substituted C2-6 alkynyloxy, unsubstituted or substituted C1-8 alkoxy, unsubstituted or substituted C3-6 cycloalkyl, unsubstituted or substituted C3-6 heteroalicyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, wherein R2 is not hydrogen, hydroxy or benzyloxy;
- or R2 and R2b or R2c, taken together with the atoms to which they are attached form a ring system;
- or R2a and R2b, or R2c and R2d, taken together with the atoms to which they are attached form a ring system;
- R3 is selected from hydrogen, deuterium, hydroxyl, —OD, unsubstituted or substituted C1-6 alkyl, unsubstituted or substituted C1-6 haloalkyl, unsubstituted or substituted C1-6 hydroxyalkyl, unsubstituted or substituted C2-6 alkenyl, unsubstituted or substituted C3-6 cycloalkyl, unsubstituted or substituted C3-6 heteroalicyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl;
- R4a, R4b, R5a, and R5b, are independently selected from the group consisting of hydrogen, deuterium, and unsubstituted or substituted C1-6 alkyl;
- wherein when m and n are 1 then R4a, R4b, R5a, R5b are hydrogen;
- R6 is selected from the group consisting of hydrogen, deuterium, halogen, hydroxyl, oxo, —OD, cyano, substituted or unsubstituted C1-4 alkyl, and substituted or unsubstituted C1-4 alkoxy, substituted or unsubstituted aryl;
- or R6 and R3, taken together with the atoms to which they are attached form a ring system;
- R7 is selected from the group consisting of hydrogen, deuterium, halogen, hydroxyl, oxo, —OD, cyano, substituted or unsubstituted C1-4 alkyl, and substituted or unsubstituted C1-4 alkoxy;
- R8 is absent, or selected from the group consisting of hydrogen, deuterium, cyano, hydroxyl, —OD, substituted or unsubstituted C1-4 alkyl, substituted or unsubstituted C2-4 alkenyl, substituted or unsubstituted C3-6 cycloalkyl, and substituted or unsubstituted C1-4 alkoxy;
- X is O or S.
13 more elements
-10. (canceled)
(canceled)
-15. (canceled)
-19. (canceled)
(canceled)
-27. (canceled)
(canceled)
(canceled)
-38. (canceled)
-44. (canceled)
(canceled)
A compound according to Formula (I)
- or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or deuterated analogue thereof, wherein:
- m, and n are independently an integer selected from the group consisting of 0, 1, 2, and 3;
- p, and q are independently an integer selected from the group consisting of 0, 1, 2, 3, and 4;
- R1 and R1d are fluoro;
- R1a, R1b, and Rc are hydrogen;
- R2 is selected from the group consisting of methoxy, ethoxy, n-propoxy, isopropoxy, allyloxy, prop-2-yn-1-yloxy, n-butoxy, iso-butoxy, tert-butoxy, pentyl-oxy, 4-methyl-butoxy, hexyl-oxy, 4-methylpentoxy, cyclopropyloxy, cyclopropylmethoxy, cyclopropylethoxy, cyclobutyloxy, cyclobutylmethoxy, cyclobutylethoxy, 2-fluoroethoxy, 3-fluoropropoxy, 4-fluorobutoxy, 2-fluoroethoxy, 3-fluoropropoxy, 2,2-difluoroethoxy, 4-methoxybutoxy, 2-hydroxyethoxy, 1,2-dihydroxyethyl, 2-hydroxy-2,3-dimethylbutoxy, —OCF3, and (1,3-difluoropropan-2-yl)oxy;
- R2a, R2b, R2c, and R2d are hydrogen;
- R3 is selected from hydrogen, deuterium, hydroxyl, —OD, unsubstituted or substituted C1-6 alkyl, unsubstituted or substituted C1-6 haloalkyl, unsubstituted or substituted C1-6 hydroxyalkyl, unsubstituted or substituted C2-6 alkenyl, unsubstituted or substituted C3-6 cycloalkyl, unsubstituted or substituted C3-6 heteroalicyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl;
- R4a, R4b, R5a, and R5b, are independently selected from the group consisting of hydrogen, deuterium, and unsubstituted or substituted C1-6 alkyl;
- wherein when m and n are 1 then R4a, R4b, R5a, R5b are hydrogen;
- R6 is selected from the group consisting of hydrogen, deuterium, halogen, hydroxyl, oxo, —OD, cyano, substituted or unsubstituted C1-4 alkyl, and substituted or unsubstituted C1-4 alkoxy, substituted or unsubstituted aryl;
- or R6 and R3, taken together with the atoms to which they are attached form a ring system;
- R7 is selected from the group consisting of hydrogen, deuterium, halogen, hydroxyl, oxo, —OD, cyano, substituted or unsubstituted C1-4 alkyl, and substituted or unsubstituted C1-4 alkoxy;
- R8 is absent, or selected from the group consisting of hydrogen, deuterium, cyano, hydroxyl, —OD, substituted or unsubstituted C1-4 alkyl, substituted or unsubstituted C2-4 alkenyl, substituted or unsubstituted C3-6 cycloalkyl, and substituted or unsubstituted C1-4 alkoxy;
- X is O or S.
12 more elements
Dependencies are inferred from the claim text.