New alkoxyamino compounds for treating pain and pain related conditions
AssigneeEsteve Pharmaceuticals, S.A.
InventorsCarmen ALMANSA-ROSALES, Félix CUEVAS-CORDOBES
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Abstract
The present invention relates to new compounds of general formula (I) showing great affinity and activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels or dual activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels, and the μ-opioid receptor (MOR or mu-opioid receptor). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.
Claims20
1-16. (canceled)
A compound of general formula (I):
- wherein:
- R1 and R1a are independently from one another a hydrogen atom or a branched or unbranched C1-6 alkyl radical;
- R2 is selected from the group consisting of an optionally substituted 6-membered aryl group and an optionally substituted 5 to 9-membered heteroaryl group having at least one heteroatom selected from the group consisting of N, O and S;
- n and m are independently 0.1 or 2;
- —W—Z moiety is in meta or para position;
- W represents —(CH2)p— —C(O)— or a bond;
- p is 1 or 2;
- Z is selected from the group consisting of an optionally substituted 5 to 9 membered heteroaryl group having at least one heteroatom selected from the group consisting of N, O and S;
- an optionally substituted 3 to 6 membered heterocycloalkyl group having at least one heteroatom selected from the group consisting of N, O and S;
- and an optionally substituted 5 to 10-membered heterocyclic system having at least one heteroatom selected from the group consisting of N, O and S;
- or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof.
A compound selected from the group consisting of:
- 3-(4-((3,4-Dihydroquinolin-(2H)-yl)methyl)-3-fluorophenoxy)-N-methyl-3-(thiophen-2-yl)propan-1-amine and
- 3-(4-((3,4-Dihydroisoquinolin-2(1H)-yl)methyl)-3-fluorophenoxy)-N-methyl-3-(thiophen-2-yl)propan-1-amine;
- or a pharmaceutically acceptable salt, stereoisomer or solvate thereof.
Dependencies are inferred from the claim text.