Methods of inhibiting kinases

A method of inhibiting a kinase, comprising:

• contacting the kinase with compound having a structure of Formula A, or derivative thereof, prodrug thereof, salt thereof, stereoisomer thereof, tautomer thereof, polymorph thereof, or solvate thereof, or having any chirality at any chiral center,
• wherein:
• ring 1 is an aromatic ring with or without hetero atoms;
• ring 2 is a hetero aromatic ring;
• ring 3 includes at least one hetero aromatic ring and optionally at least one cycloaliphatic ring fused with the at least one hetero aromatic ring;
• ring 4 is an aromatic ring with or without hetero atoms;
• Y is a bond or a linker;
• Y1 is a linker;
• each n is independently 0, 1, or 2;
• each o is independently 0, 1, 2, 3, 4, or 5;
• each R1, R6, R11, and R12 is independently a substituent;
• and
• RA is a ring structure, straight aliphatics, or branched aliphatics, which can be substituted or unsubstituted, any with or without hetero atoms.