Benzothiazol compounds and methods using the same for treating neurodegenerative disorders

A method for treating a neurodegenerative disease in a subject, comprising:

• administering to the subject in need thereof a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof:
• wherein:
• R1 is cyclopropyl, wherein R1 is substituted with one or more groups selected from the group consisting of halo, alkyl, hydroxyalkyl and haloalkyl,
• R2 and R3 are independently —H, halo, alkyl, alkoxy, —CF3, or —OCF3,
• R4 is aryl, monocyclic heteroaryl, cycloalkyl, or heterocyclyl, wherein R4 is optionally substituted with one or more groups selected from the group consisting of halo, hydroxyl, alkyl, alkenyl, alkynyl, haloalkyl, hydroxyalkyl, trimethylsilylethoxymethyl, —NO2, —NRaRb, —NRaC(═O)Rb, —NRaC(═O)NRaRb, —NRaC(═O)ORb, —ORa, —CN, —C(═O)Ra, —C(═O)ORa, —C(═O)NRaRb, —OC(═O)Ra, —OC(═O)ORa, —OC(═O)NRaRb, —SRa, azetidinyl, oxetanyl, tetrahydrofuranyl, furanyl, pyrrolidinyl, pyrrolyl, pyrazolyl, thiophenyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, furazanyl, oxadiazolyl, thiadiazolyl, phenyl, tetrahydropyranyl, pyranyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, piperidinyl, piperazinyl, morpholinyl and thiomorpholinyl, and
• Ra and Rb are independently —H, halo, amino, alkyl, or haloalkyl.