Crystalline forms of (s)-afoxolaner
AssigneeBoehringer Ingelheim Animal Health USA Inc.
InventorsRoelof Johannes Gorter de Vries, Bruno Baillon, Sylvaine Lafont, Myriam Gay de Saint Michel, Stephane Kozlovic
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Abstract
The present invention provides crystalline forms of compound of formula (Ia) and processes of making the crystalline forms. Also provided are compositions comprising the crystalline forms and methods of use of the crystalline forms.
Claims34
A crystalline compound of formula (Ia), designated as Form I,
- wherein said crystals are characterized by having an x-ray powder diffraction pattern comprising three, four, five, six, seven or more peaks selected from the group consisting of:
- 10.03°, 10.48°, 13.16°, 15.42°, 15.80°, 16.07°, 17.65°, 20.16°, 22.15°, 23.68°, 26.52°, and 28.13° 2θ±0.2 as determined on a diffractometer using Cu-Kα radiation.
A crystalline compound of formula (Ia), designated as Form II,
- wherein said crystals are characterized by having an x-ray powder diffraction pattern comprising three, four, five, six, seven or more peaks selected from the group consisting of:
- 5.99°, 12.99°, 15.80°, 18.71°, 19.33°, 20.24°, 21.65°, 22.17°, 26.11° and 29.00° 2θ±0.2 as determined on a diffractometer using Cu-Kα radiation.
The crystalline compound of formula (Ia) according to any one of claims 11 to 16, characterized by having a differential scanning calorimetry thermogram substantially similar to FIG. 4.
Dependencies are inferred from the claim text.