US 2020/0270209 A1 · MONO- OR DI-SUBSTITUTED INDOLE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS

Abstract

The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using the compounds and also relates to use of the compounds as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

Claims29

Dependent claims

A compound of formula (I)

wherein R1, R2 and R3 are selected from the group consisting of:
R1 is H, R2 is F and R3 is H or CH3,
R1 is H, CH3 or F, R2 is OCH3 and R3 is H,
R1 is H, R2 is OCH3 and R3 is CH3,
R1 is CH3, R2 is F and R3 is H,
R1 is CF3, R2 is H and R3 is H,
R1 is OCF3, R2 is OCH3 and R3 is H, and
R1 is OCF3, R2 is H and R3 is CH3,
or a stereoisomer, pharmaceutically acceptable salt, solvate or polymorph thereof.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/930,738Filed 13 May 2020

Priority

EP 15166900.98 May 2015

Published

27 Aug 2020

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

C07D 209/14
With substituted hydrocarbon radicals attached to carbon atoms of the hetero ring: radicals substituted by nitrogen atoms, not forming part of a…
A61K 31/404
Condensed with carbocyclic rings, e.g. carbazole: indoles, e.g. pindolol
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
A61P 31/14
Antivirals: for RNA viruses

Mono- or di-substituted indole derivatives as dengue viral replication inhibitors

Life of this patent

Mono- or di-substituted indole derivatives as dengue viral replication inhibitors

Life of this patent

Abstract

Claims29