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US 2020/0270201 A1Published application
Biphenyl amides with modified ether groups as hsp90 inhibitors and hsp70 inducers
AssigneeUniversity of Kansas
InventorsBrian S.J. BLAGG, Rick T. DOBROWSKY, Mercy ANYIKA
Life of this patent
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Abstract
Provided herein are compounds of the formulas: wherein: n, X2, R3, R3′, R4, R4′, R5, R5′, R6, and R6′ are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including diabetic peripheral neuropathy or cancer.
Claims25
A compound of the formula:
- wherein:
- R7 is aryl(C≤12), aralkyl(C≤12), or a substituted version of either of these groups;
- R8 is hydrogen, alkyl(C≤12), cycloalkyl(C≤12), substituted alkyl(C≤12), or substituted cycloalkyl(C≤12);
- R9 is alkyl(C≤12), cycloalkyl(C≤12), aryl(C≤12), heteroaryl(C≤12), or a substituted version of any of these groups;
- and
- Y1 and Y2 are each independently hydrogen or hydroxy;
- or a pharmaceutically acceptable salt thereof.
4 more elements
-43. (canceled)
(canceled)
A compound of the formula:
- wherein:
- the bond between atom 1 and atom 2 is either a single bond or a double bond;
- X1 is aryl(C≤12), heteroaryl(C≤12), or a substituted version of either of these groups;
- X2 is —O—;
- R1 is acyl(C≤12) or substituted acyl(C≤12);
- R2 is hydrogen, alkyl(C≤12), or substituted alkyl(C≤12);
- R3, R4, R3′, R4′ are each independently hydrogen, hydroxy, aryloxy(C≤12), aralkoxy(C≤12), substituted aryloxy(C≤12), or substituted aralkoxy(C≤12);
- each R5 and R5′ are each independently hydrogen, hydroxy, heteroaryloxy(C≤12), heteroaralkoxy(C≤12), substituted aryloxy(C≤12), substituted aralkoxy(C≤12), substituted heteroaryloxy(C≤12), or substituted heteroaralkoxy(C≤12);
- R6 and R6′ are each independently hydrogen, alkyl(C≤12), cycloalkyl(C≤12), substituted alkyl(C≤12), or substituted cycloalkyl(C≤12);
- and
- n is 0, 1, or 2;
- provided that if n is 2 then the R5 and R5′ on each methylene are independently selected;
- or a pharmaceutically acceptable salt thereof.
10 more elements
-107. (canceled)
-191. (canceled)
-226. (canceled)
Dependencies are inferred from the claim text.