Method and device for enhancing memory consolidation
AssigneesIcm (Institut Du Cerveau Et De La Moelle éPinièRe), Aphp (Assistance Publique - HôPitaux De Paris), Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite, Inserm (Institut National De La Sante Et De La Recherche Medicale)
InventorsMichel LE VAN QUYEN, Stéphane CHARPIER, Séverine MAHON
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Abstract
The present invention relates to methods and devices to consolidate memory and/or cognitive functions by monitoring brain rhythms and delivering a stimulus at an appropriate stage of sleep cycle.
Claims23
-15. (canceled)
A non-invasive method for monitoring a subject's brain activity and emitting stimuli according to said subject's brain activity, said method comprising:
- I. receiving a brain activity signal measured by a monitoring device for measuring said subject's brain activity;
- II. monitoring said brain activity signal,
- III. detecting in said brain activity signal an end of a stage I of a non-REM light sleep state, by detection of a negative peak with an amplitude inferior to −75 μV, and an onset of a stage II of said non-REM light sleep state,
- IV. emitting a first stimulus at the detection of the onset of stage II of said non-REM light sleep state,
- V. emitting a second stimulus,
- VI. repeating emitting the first stimulus and the second stimulus until an end of a stage IV of said non-REM light sleep state, and
- VII. restarting steps IV to VII when an onset of a further stage II of said non-REM light sleep state is detected.
A device for implementing a non-invasive method for monitoring a subject's brain activity and emitting stimuli according to said subject's brain activity, comprising:
- a. a monitoring device for measuring said subject's brain activity;
- b. a stimulation device providing at least one type of stimulus;
- and
- c. a programmable microcontroller board configured to perform the steps of:
- I. receiving a brain activity signal measured by said monitoring device;
- II. monitoring said brain activity signal;
- III. detecting in said brain activity signal the end of a stage I of a non-REM light sleep state by detection of a negative peak with an amplitude inferior to −75 μV and an onset of stage II of a non-REM light sleep state;
- IV. causing the stimulation device to emit a first stimulus at the detection of the onset of stage II of a non-REM light sleep state;
- V. causing the stimulation device to emit a second stimulus;
- VI. causing the stimulation device to repeat the emission of the first stimulus and the second stimulus until an end of stage IV of a non-REM light sleep state;
- and
- VII. repeating steps IV to VII when the onset of stage II of a non-REM light sleep state is detected.
Dependencies are inferred from the claim text.