Brain damage recovery material

A method for producing a brain damage repair material, the method comprising at least the steps of:

• (1) mixing a solution containing a low endotoxin bioabsorbable polysaccharide having a carboxyl group in a molecule thereof and at least one crosslinking reagent selected from a compound represented by general formula (I) and a salt thereof;
• (2) placing in a mold a mixture obtained in (1) with a bioabsorbable polymer and allowing the same to stand still for a certain amount of time to obtain a crosslinked product;
• (3) washing the crosslinked product obtained in (2) followed by lyophilizing the same;
• and
• (4) irradiating the crosslinked product obtained in (3) with an electron beam and/or gamma rays.

A method of treating brain damage comprising administering to a subject in need thereof a non-tubular brain damage repair material which covers and/or fills a damaged site of a brain, comprising:

• (A) a crosslinked product in which a low endotoxin bioabsorbable polysaccharide having a carboxyl group in a molecule thereof is covalently crosslinked with at least one crosslinking reagent selected from a compound represented by general formula (I) below and a salt thereof;
• and
• (B) a bioabsorbable polymer:
• R1HN—(CH2)n—NHR2 (I)
• wherein, R1 and R2 each independently represent a hydrogen atom or a group represented by the formula:
• —COCH(NH2)—(CH2)4—NH2, and n represents an integer of 2 to 18.