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US 2020/0268902 A1Published application
Methods and compositions for cancer treatment
AssigneeDingfu Biotarget Co., Ltd.
InventorsTing XU, Yan LUAN, Shilong FU, Songbing QIN, Jian DING, Kai FU
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Abstract
Provided are compositions and methods for treating cancer comprising the use of a immunoconjugate in combination with a cytotoxic agent or cytotoxic therapy. The immunoconjugate in combination with a cytotoxic agent or cytotoxic therapy shows synergistic effects in cancer treatment.
Claims23
A composition comprising an immunoconjugate and a cytotoxic agent, wherein:
- said immunoconjugate comprises 1) one or more interleukins, and 2) an Fc domain consisting of a first Fc subunit and a second Fc subunit, said first Fc subunit associates with said second Fc subunit to form a dimer;
- said one or more interleukins are fused to said Fc domain;
- and
- wherein said cytotoxic agent is capable of inducing immunogenic cell death.
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Dependencies are inferred from the claim text.