USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION-INDUCED CARDIOVASCULAR DYSFUNCTION
AssigneeThe Trustees of the University of Pennsylvania
InventorMelpo CHRISTOFIDOU-SOLOMIDOU
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Abstract
The invention relates to the use of secoisolariciresinol diglucoside (SDG), obtained from natural sources, such as flaxseed, or generated synthetically (synthetic SDG is also referred to herein as LGM2605), other active components in flaxseed, secoisolariciresinol (SECO), enterodiol (ED), and enterolactone (EL), as well as stereoisomers of the foregoing, metabolites of the foregoing, degradants of the foregoing, and analogs of the foregoing, to treat and protect cardiac and vascular tissues, for example, treating ionizing radiation-associated vascular injury and vasculopathy and protecting vascular tissue against ionizing radiation exposure.
Claims65
A method for treating or preventing radiation-associated vascular injury in a subject in need thereof, the method comprising:
- administering to said subject an effective amount of secoisolaricirecinol diglucoside (SDG), an analog thereof, a stereoisomer thereof, or a combination thereof, thereby treating said radiation-induced vascular damage in said subject.
A method for improving arterial blood oxygenation in a subject who has been or will be exposed to ionizing radiation, the method comprising:
- administering to said subject an effective amount of secoisolaricirecinol diglucoside (SDG), an analog thereof, a stereoisomer thereof, or a combination thereof, thereby improving arterial blood oxygenation in said subject.
A method for protecting vascular tissue against ionizing radiation exposure in a subject in need thereof, the method comprising:
- administering to said subject an effective amount of secoisolaricirecinol diglucoside (SDG), an analog thereof, a stereoisomer thereof, or a combination thereof, thereby protecting normal vascular tissue against ionizing radiation exposure in said subject.
A method for reducing or preventing ionizing radiation-associated blood vessel wall scarring in a subject in need thereof, the method comprising:
- administering to said subject an effective amount of secoisolaricirecinol diglucoside (SDG), an analog thereof, a stereoisomer thereof, or a combination thereof, thereby reducing or preventing ionizing radiation-associated blood vessel wall scarring in said subject.
Dependencies are inferred from the claim text.