Use of nicotinamide riboside, nicotinic acid riboside, reduced nicotinyl riboside compounds, and nicotinyl riboside compound derivatives in formulations

A process for making wax prills containing one or more nicotinyl riboside compounds selected from the group consisting of nicotinamide riboside (NR, I), nicotinic acid riboside (NAR, II), nicotinamide mononucleotide (NMN, III), nicotinic acid mononucleotide (NaMN, IV), reduced nicotinamide riboside (NRH, V), reduced nicotinic acid riboside (NARH, VI), NR triacetate (NRTA, VII), NAR triacetate (NARTA, VIII), NRH triacetate (NRH-TA, IX), NARH triacetate (NARH-TA, X), and salts or mixtures thereof;

• comprising the steps of:
• (a) preparing a mixture of a nicotinyl riboside and a hydrogenated oil selected from sunflower oil or palm oil;
• (b) spray melting the mixture at a temperature below about 90° C. and a flow rate of at least about 4 kg/hour;
• (c) allowing solidification of the sprayed mixture in cold air to provide generally spherical wax prills;
• and
• (d) isolating the generally spherical wax prills.

A process for making wax prills containing one or more nicotinyl riboside compounds selected from the group consisting of nicotinamide riboside (NR, I), nicotinic acid riboside (NAR, II), nicotinamide mononucleotide (NMN, III), nicotinic acid mononucleotide (NaMN, IV), reduced nicotinamide riboside (NRH, V), reduced nicotinic acid riboside (NARH, VI), NR triacetate (NRTA, VII), NAR triacetate (NARTA, VIII), NRH triacetate (NRH-TA, IX), NARH triacetate (NARH-TA, X), and salts or mixtures thereof;

• comprising the steps of:
• (a) preparing a mixture of a nicotinyl riboside and an edible oil and/or wax;
• (b) spray melting the mixture at a temperature above the melting point of the oil and/or wax;
• (c) allowing solidification of the sprayed mixture in cold air to provide generally spherical wax prills;
• and
• (d) isolating the generally spherical wax prills.

A composition, comprising encapsulated beads, comprising:

• one or more nicotinyl riboside compounds selected from the group consisting of nicotinamide riboside (NR, I), nicotinic acid riboside (NAR, II), nicotinamide mononucleotide (NMN, III), nicotinic acid mononucleotide (NaMN, IV), reduced nicotinamide riboside (NRH, V), reduced nicotinic acid riboside (NARH, VI), NR triacetate (NRTA, VII), NAR triacetate (NARTA, VIII), NRH triacetate (NRH-TA, IX), NARH triacetate (NARH-TA, X), and salts or mixtures thereof;
• one or more vitamins selected from the group consisting of vitamin B1 (thiamine, XII), vitamin B2 (riboflavin, XIII), vitamin B3 (niacin, XI), vitamin B6 (pyridoxine, XIV), vitamin B7 (biotin, XV), vitamin B9 (folic acid, XVI), vitamin B12 (cobalamin, XVII), vitamin A1 (retinol, XVIII), vitamin C (ascorbic acid, XIX), vitamin D3 (cholecalciferol, XX), vitamin D2 (ergocalciferol, XXI), vitamin E (alpha-tocopherol, XXII), vitamin K1 (phytomenadione, XXIII), and mixtures thereof;
• wherein the beads comprise sodium alginate, calcium alginate, chocolate coating, liposomes, phospholipids, glycolipids, and mixtures thereof;
• and optionally an edible oil and/or wax selected from the group consisting of palm oil, sunflower oil, carnauba wax, cottonseed oil, soybean oil, cocoa butter, paraffin wax, bees wax, high oleic safflower oil, soy oil, fractionated coconut oil, medium chain triglycerides, MCT oil, high oleic sunflower oil, corn oil, canola oil, coconut oil, palm kernel oil, marine oil, walnut oil, wheat germ oil, sesame oil, cod liver oil, candelilla wax, palm stearin, rapeseed oil, glycerol dibehenate, glycerol distearate, peanut oil, and mixtures thereof.