Compositions and methods for promoting hematopoietic stem cell regeneration
AssigneeDuke University
InventorLuigi Racioppi
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Abstract
Described is a method for promoting regeneration of hematopoietic stem and progenitor cells in a subject in need thereof. The method comprises administering to the subject a composition comprising a Ca2+/calmodulin (CaM)-dependent protein kinase kinase 2 (CaMKK2) inhibitor. The CaMKK2 inhibitor may be a small molecule inhibitor, such as 7H-benzimidazo(2,1-a)benz(de)isoquinoline-7-one-3-carboxylic acid (STO-609).
Claims11
A method of promoting regeneration of hematopoietic stem and progenitor cells (HSPCs) in a subject in need thereof, the method comprising administering to the subject an effective amount of a composition comprising a CaMKK2 inhibitor.
Dependencies are inferred from the claim text.