Methods for treating diseases or infections caused by or associated with h. pylori using a halogenated salicylanilide
AssigneeRhode Island Hospital
InventorsEleftherios MYLONAKIS, Nagendran THARMALINGAM
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Abstract
Disclosed are methods for the prevention or treatment of a disease or infection caused by or associated with H. Pylori in a subject infected by H. Pylori, the method comprising orally administering a halogenated salicylanilide such as niclosamide to the subject. The method may be used for the prevention or treatment of, for example dyspepsia, gastritis, peptic ulcer disease, premalignant gastric lesions, gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) lymphoma.
Claims28
A method for the prevention or treatment of a disease or infection caused by or associated with H. Pylori in a subject infected with H. Pylori, the method comprising orally administering to the subject an effective amount of a halogenated salicylanilide, or a pharmaceutically acceptable salt or solvate thereof.
A method for eradicating a H. Pylori infection in a subject with a disease or infection caused by or associated with H. Pylori, the method comprising orally administering to the subject an effective amount of a halogenated salicylanilide, or a pharmaceutically acceptable salt or solvate thereof.
A method for eradicating a H. Pylori infection in a subject, wherein the subject has a premalignant gastric epithelial lesion, the method comprising orally administering to the subject an effective amount of a halogenated salicylanilide, or a pharmaceutically acceptable salt or solvate thereof.
A method for treating or preventing atrophic gastritis in a subject infected with H. Pylori, the method comprising orally administering to the subject an effective amount of a halogenated salicylanilide, or a pharmaceutically acceptable salt or solvate thereof, wherein the method reduces H. Pylori induced IL-8 secretion in the subject.
Dependencies are inferred from the claim text.