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US 2020/0268679 A1Published application
Hydrophobic ion pairing and flash nanoprecipitation for formation of controlled-release nanocarrier formulations
AssigneeThe Trustees of Princeton University
InventorsRobert K. PRUD'HOMME, Kurt D. RISTROPH, Nathalie M. PINKERTON, Hoang D. LU, Paradorn RUMMANEETHORN
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Abstract
Methods for encapsulating water-soluble biologic and small molecule active pharmaceutical ingredients (APIs) into nanoparticles by applying nanoprecipitation techniques and ion-pairing the nanoparticles with hydrophobic counterions to produce new API salts that exhibit altered solubilities are presented.
Claims188
A nanoparticle, comprising:
- a modified salt comprising a water-soluble active pharmaceutical ingredient (API) ion paired with a hydrophobic counterion of an ion pairing (IP) reagent;
- and
- a nanoparticle encapsulant material substantially surrounding the modified salt.
A method for encapsulating an active pharmaceutical ingredient (API), comprising:
- producing a hydrophobic salt by ion pairing charged functional groups on a water soluble API with an ion pairing (IP) reagent;
- and
- forming nanoparticles that are carriers of the hydrophobic salt to encapsulate the API,
- wherein the IP reagent comprises a counterion for the API.
1 more element
Dependencies are inferred from the claim text.