Minimizing aeration of suspensions during in-line mixing
AssigneeCatalent U.K. Swindon Zydis Limited
InventorsRosaleen MCLAUGHLIN, Simon Andrew Martyn HOWES, Jonathon WHITEHOUSE
Life of this patent
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Abstract
Provided are pharmaceutical compositions and methods for preparing pharmaceutical compositions that can minimize the aeration a pharmaceutical suspension during the production process. Pharmaceutical compositions include a plurality of API particles; a coating material encapsulating each API particle of the plurality of API particles; and a matrix solution/suspension comprising a matrix former, a structure former, and an anti-aerating agent.
Claims47
A method of making a pharmaceutical composition comprising:
- providing a matrix solution/suspension comprising a matrix former, a structure former, an anti-aerating agent, and a solvent;
- and
- mixing a plurality of hydrophobic particles into the matrix solution/suspension to form a pharmaceutical suspension;
- and
- dosing the pharmaceutical suspension into preformed blister packs, wherein a dosed weight of the dosed pharmaceutical suspension is within 10% of a target dosed weight.
A pharmaceutical composition prepared by a process comprising the steps of:
- providing a matrix solution/suspension comprising a matrix former, a structure former, an anti-aerating agent, and a solvent;
- and
- mixing a plurality of hydrophobic particles into the matrix solution/suspension to form a pharmaceutical suspension;
- and
- dosing the pharmaceutical suspension into preformed blister packs, wherein a dosed weight of the dosed pharmaceutical suspension is within 10% of a target dosed weight.
A pharmaceutical composition comprising:
- a plurality of API particles;
- a coating material encapsulating each API particle of the plurality of API particles;
- a matrix former;
- a structure former;
- and
- an anti-aerating agent.
Dependencies are inferred from the claim text.