Trans-Catheter Local Immunotherapy for Solid Tumors

A method of treating a tumor with a substance, the method comprising:

• introducing a catheter into a blood vessel that supplies blood to the tumor;
• inflating a balloon to block the blood vessel;
• introducing the substance into the blood vessel at a position that is distal with respect to the inflated balloon at a pressure that is sufficient to overcome a region of high pressure in a vicinity of the tumor;
• and
• introducing an embolization agent into the blood vessel after the substance has been introduced into the blood vessel, at a position that is proximal with respect to at least a portion of the substance,
• wherein the embolization agent acts to prevent retrograde washout of the substance and impede systemic release by impeding the forward flow of blood.

A method of treating a tumor with a substance, the method comprising:

• introducing a catheter into a blood vessel that supplies blood to the tumor;
• inflating a balloon to block the blood vessel;
• and
• introducing a liquid in which a plurality of substance-eluting beads are suspended into the blood vessel at a position that is distal with respect to the inflated balloon at a pressure that is sufficient to overcome a region of high pressure in a vicinity of the tumor.