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US 2020/0268503 A1Published application
In Vivo Tissue Engineering Devices, Methods and Regenerative and Cellular Medicine Employing Scaffolds Made of Absorbable Material
AssigneeBard Shannon Limited
InventorRobert D. Rehnke
Life of this patent
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Abstract
Tissue engineering devices and methods employing scaffolds made of absorbable material for use in the human body for tissue genesis and regenerative and cellular medicine including breast reconstruction and cosmetic and aesthetic procedures and supplementing organ function in vivo.
Claims32
A tissue engineering device for implant in an anatomical space in fascia of the human body comprising
- a scaffold made of porous absorbable material having a proximal portion for positioning within the fascia, a distal portion spaced from said proximal portion, a hollow central core extending between said proximal portion and said distal portion, and a sidewall surrounding said hollow central core;
- and
- a plurality of partially open, tissue engineering chambers formed in said side wall and radially arranged around said hollow central core, said tissue engineering chambers having an aggregate surface area greater than the fascia surface area in the anatomical space.
A tissue engineering method comprising the steps of
- implanting a scaffold made of porous absorbable material in fascia in the human body, the scaffold including a proximal portion, a distal portion spaced from the proximal portion and an intermediate portion extending between the proximal portion and the distal portion, the intermediate portion having a plurality of outwardly facing partially open compartments forming tissue engineering chambers for the scaffold and the intermediate portion defining a hollow inner region for the scaffold, said implanting step including
- anchoring the proximal portion of the scaffold to the fascia:
- inserting autologous tissue in the tissue engineering chambers;
- pulling a vascular flap pedicle of the fascia along with the blood vessels into the hollow inner region of the scaffold;
- and
- positioning the vascular flap pedicle in the distal portion of the scaffold to position the blood vessels along the hollow inner region to provide capillary blood supply to the autologous tissue in the tissue engineering chambers.
3 more elements
A tissue engineering device for implant in an anatomical space in fascia in the human body comprising
- a scaffold made of porous absorbable material having a proximal portion for positioning within the fascia, a distal portion spaced from said proximal portion, a central core extending between said proximal portion and said distal portion, and a sidewall surrounding said central core, said side wall being formed by a plurality of adjacent rings of tissue engineering chambers, each of said rings including a plurality of partially open tissue engineering chambers radially arranged around said central core.
A tissue engineering device for implant in the breast of the human body comprising
- a scaffold having a base portion, an apex portion spaced from said base portion and a hollow inner region extending between said base portion and said apex portion, said base portion having a crosswise dimension and said apex portion having a crosswise dimension less than said crosswise dimension of said base portion, and a plurality of tissue engineering chambers arranged around said hollow inner region to form a tapering sidewall for said scaffold,
- said scaffold being formed of absorbable mesh material allowing arterial and tissue ingrowth in said tissue engineering chambers and in said hollow inner region.
A tissue engineering device for implant in the breast of the human body comprising
- a scaffold having a truncated geometrical shape with a base, an apex axially spaced from said base and a side wall tapering from said base to said apex;
- a hollow core extending between said base and said apex;
- a plurality of tissue engineering chambers arranged around said core;
- and
- said scaffold being formed of one or more mesh sheets of absorbable material allowing ingrowth of tissue and blood vessels in said tissue engineering chambers and in said hollow core.
2 more elements
A tissue engineering device for implant in an anatomical space in the human breast after a lumpectomy comprising
- a scaffold made of porous absorbable material and having a spherical-type shape with a hollow central core and a plurality of partially open, tissue engineering chambers disposed around said central core, said tissue engineering chambers being arranged to accommodate tissue ingrowth and adipogenesis whereby the outer shape of said scaffold substantially matches the shape of the anatomical space in the breast.
Dependencies are inferred from the claim text.