Pct and pro-adm as markers for monitoring antibiotic treatment

Abstract

A method for antibiotic therapy guidance, stratification and/or control in a patient suffering from an infectious disease and receiving treatment with one or more antibiotic agents. The method comprises isolating a first and subsequently second sample from said patient and initiating antibiotic treatment, determining levels of procalcitonin (PCT) or fragment(s) thereof in both samples, and determining a level of proadrenomedullin (proADM) or fragment(s) thereof in at least the second sample, wherein the levels of PCT or fragment(s) thereof in said samples, and the level of proADM or fragment(s) thereof in the second sample, indicate whether a change in the treatment with one or more antibiotic agents is required. The method may comprise additionally determining a level of proADM or fragment(s) thereof in the first sample. Changes in the proADM and PCT levels between the first and second samples may indicate a need for changing the antibiotic treatment.

Dependencies are inferred from the claim text.