Global proteomic screening of random bead arrays using mass spectrometry imaging
AssigneeAmberGen, Inc.
InventorsMark J. Lim, Vladislav B. Bergo, Kenneth J. Rothschild
Life of this patent
Estimating the term…
Abstract
Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
Claims11
1-36. (canceled)
A composition comprising a mass-tag attached to a probe, said composition having the following structure:
- wherein X is a spacer.
A composition having the following structure:
- a. wherein X is a mass-tag;
- b. wherein B is a spacer;
- and
- c. wherein Y is a reactable moiety.
Dependencies are inferred from the claim text.