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US 2020/0264128 A1Published application
Methods and apparatus for measuring analytes including chemical sensor array
AssigneeLife Technologies Corporation
InventorsJonathan M. ROTHBERG, Todd REARICK
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Abstract
Methods and apparatus relating to FET arrays including large FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.
Claims13
A system for chemical analysis comprising:
- an array of pixels having a plurality of rows and a plurality of columns, each of the pixels having a reaction area and a chemically sensitive sensor configured to provide an analog output indicative of the reactions sensed within the reaction area for the pixel;
- a selection circuit arranged to select at least one of the rows;
- a plurality of column circuits, each column circuit configured to receive the analog output from a selected row during a sampling period;
- an analog to digital conversion circuit associated with each of the column circuits and configured to receive the analog output from the column circuits that were received by the column circuits during the sampling period and to sample them at a second rate that is greater than a first rate, such that a series of samples is made for each of the analog outputs at the second rate for a second sampling period that corresponds to the sampling period;
- and
- an estimation device that receives that series of samples and determines an estimated pixel value from the series of samples during the sampling period.
3 more elements
A method of determining pixel values comprising:
- providing an array of pixels arranged in a plurality of rows and a plurality of columns;
- selecting at least one row of pixels to be read out of the array;
- outputting pixel data for the at least one row onto a column bus at a first rate;
- and converting pixel data from the column bus at a second rate that is multiple times the first rate such that an oversampled pixel data set is made for each pixel readout.
1 more element
Dependencies are inferred from the claim text.