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US 2020/0264079 A1Published application
Cryogenic transmission electron microscopy sample preparation
AssigneeNanoSoft, LLC
InventorsMichael Godfrin, Michael Franzblau
Life of this patent
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Abstract
A method includes introducing a fluidic sample into a void volume of a porous material, bringing the porous material into contact with a hydrophilic substrate compatible with a cryogenic Transmission Electron Microscope, separating the porous material from the substrate, and transferring a portion of the sample from the porous material to the substrate between their contact and separation.
Claims7
A method comprising:
- introducing a fluidic sample into a void volume of a porous material;
- bringing the porous material into contact with a hydrophilic substrate compatible with a cryogenic Transmission Electron Microscope;
- separating the porous material from the substrate;
- and
- transferring a portion of the sample from the porous material to the substrate between their contact and separation.
2 more elements
A method comprising:
- loading a hydrophilic porous material with a volume of fluidic sample wherein a portion of a void space of the hydrophilic porous material is filled with the fluidic sample;
- processing a substrate for cryo-Transmission Electron Microscope samples to be rendered hydrophilic;
- bringing the porous material into contact with a surface of the substrate, causing a volume of sample transferred from the hydrophilic porous material to the substrate;
- separating a surface of the porous material from the surface of the substrate;
- and
- plunging the substract into a liquid cryogen for sample vitrification.
3 more elements
A method comprising a blotless technique for depositing fluidic sample onto a substrate for cryo-Transmission Electron Microscope.
Dependencies are inferred from the claim text.