Method and Kit for Predicting Susceptibility to Allergic Reaction
AssigneeApollonian Biosystems Limited
InventorsSee-Ying TAM, Yee San Issan TAM, Hang Yung Alaster LAU
Life of this patent
Estimating the term…
Abstract
The present invention relates to a kit for determining susceptibility to an allergic reaction for a subject. The kit includes a probe for identifying a target biomarker, and an instruction that indicates the subject's susceptibility to the allergic reaction. The present invention also relates to a method of predicting susceptibility to an allergic reaction for a subject and treating and/or preventing the allergic reaction.
Claims20
A kit for determining susceptibility to an allergic reaction for a subject, comprising:
- (a) a probe for identifying a target biomarker from a biological sample of the subject;
- and
- (b) an instruction that indicates the subject's susceptibility to the allergic reaction by comparing an expression level of the target biomarker in the biological sample of the subject with a threshold,
- wherein the target biomarker is selected from a group consisting of neural EGFL like 2 protein (NELL2), A-kinase anchor protein 12 (AKAP12), integral membrane protein 2C (ITM2C), interleukin 13 receptor subunit alpha 1 (IL13RA1) and any combination thereof,
- wherein the threshold is defined as the mean of expression levels of the target biomarker in the biological samples of subjects who have an average risk of undergoing an allergic reaction.
A method of treating or preventing an allergic reaction in a subject, comprising:
- obtaining a biological sample from the subject;
- comparing an expression level of a target biomarker in the biological sample of the subject with a threshold,
- wherein the target biomarker is selected from a group consisting of neural EGFL like 2 protein (NELL2), A-kinase anchor protein 12 (AKAP12), integral membrane protein 2C (ITM2C), interleukin 13 receptor subunit alpha 1 (IL13RA1) and any combination thereof;
- and
- wherein the threshold is defined as the expression level of the target biomarker in the biological sample of a subject who has an average risk of the allergic reaction,
- identifying the subject as having a high susceptibility to the allergic reaction if the expression level of the target biomarker in the biological sample of the subject is higher than the threshold;
- and
- administering to the subject having the high susceptibility an anti-allergic drug for treatment or prevention of the allergic reaction, or
- treating or preventing the subject having the high susceptibility by prescribing a diet or treatment regimen wherein the subject avoids contacting an allergen associated with the allergic reaction.
A kit for determining susceptibility to an allergic reaction for a subject, comprising:
- a first probe for identifying A-kinase anchor protein 12 (AKAP12) from a biological sample of the subject;
- a second probe for identifying neural EGFL like 2 protein (NELL2) from the biological sample of the subject;
- a third probe for identifying integral membrane protein 2C (ITM2C) from the biological sample of the subject;
- and
- a fourth probe for identifying interleukin 13 receptor subunit alpha 1 (IL13RA1) from the biological sample of the subject.
Dependencies are inferred from the claim text.