Non-Neuroinvasive Viruses and Uses Thereof
AssigneesNorthwestern University, Board of Regents of the University of Nebraska, Trustees of Tufts College (AKA Tufts University)
InventorsGregory A. Smith, Patricia Jane Sollars, Gary Edward Pickard, Ekaterina E. Heldwein
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Abstract
Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.
Claims32
A variant herpesvirus or alphaherpes virus particle comprising at least one mutation in a UL37 protein, wherein said virus particle exhibits reduced neuro-invasiveness relative to a virus particle lacking said mutation.
A variant HSV 1 or 2 particle comprising a mutant UL37 protein, wherein said mutant UL37 protein comprises one or more mutations selected from the group consisting of Q403A, E452A, Q455A, Q511A, and R515A.
A variant VZV virus particle comprising a mutant UL37 protein, wherein said mutant UL37 protein comprises one or more mutations selected from the group consisting of Q363A, D413A, Q416A, Q472A, and R476A.
A variant PRV particle comprising a mutant UL37 protein, wherein said mutant UL37 protein comprises one or more mutations selected from the group consisting of Q324A, D362A, R365A, H421A, and H425A.
Dependencies are inferred from the claim text.