Non-neuroinvasive viruses and uses thereof
AssigneesNorthwestern University, Board of Regents of the University of Nebraska, Trustees of Tufts College (AKA Tufts University)
InventorsGregory A. Smith, Patricia Jane Sollars, Gary Edward Pickard, Ekaterina E. Heldwein
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Abstract
Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.
Claims33
A variant herpesvirus or alphaherpes virus particle comprising at least two mutations in a UL37 protein selected from the group consisting of SEQ ID NOs:
- 22-33, SEQ ID NO:
- 36, a sequence having 90% identity to one of SEQ ID NO:
- 22-33, and a sequence having 90% identity to SEQ ID NO:
- 36, wherein the mutations, wherein the mutations are at positions selected from the group consisting of Q403, E452, Q455, Q511, and R515 in SEQ ID NO:
- 22 or the mutations are at positions corresponding to positions Q403, E452, Q455, Q511, and R515 of SEQ ID NO:
- 22 in one of SEQ ID NOs:
- 23-33 or 36, wherein said virus particle exhibits reduced neuro-invasiveness relative to a virus particle lacking said mutation, and wherein the ability of the virus to replicate in peripheral tissues is retained.
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The method of claim 25, wherein said subject is a non-human animal.
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Dependencies are inferred from the claim text.