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US 2020/0263084 A1Published application
Condensed polycyclic conjugated polymers and their use for biological detection
AssigneeAAT Bioquest, Inc.
InventorsZhenjun Diwu, Haitao Guo, Jixiang Liu, Qin Zhao, Ruogu Peng
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Abstract
Fluorescent water soluble conjugated polymers including polycyclic aromatic comonomers are provided. The conjugated polymers can be linked to an acceptor fluorescent dye. The conjugated polymers find use in conjugates with biological substrates having applications in a variety of applications including methods of analyte detection.
Claims21
A conjugated polymer of Formula 1 comprising a conjugated segment composed of x distinct comonomer units (Mr-1 to Mr-x) that are randomly distributed along the conjugated polymer backbone:
- wherein:
- Mr-1 is a condensed polycyclic aromatic or heteroaromatic comonomer comprising four or more 5-membered and/or 6-membered rings;
- Mr-2 to Mr-x are distinct comonomer units each independently selected from ethenylene, acetylene, an aryl, a heteroaryl, and a fluorescent dye FD;
- m1 is an integer greater than or equal to 5;
- and
- m2 to mx are each independently an integer from 0 to 200;
- wherein:
- (1) the sum of m1 through mx is ≥10;
- and
- (2) at least one comonomer of Mr1 to Mr-X comprises a water soluble group (WSG);
- and
- (3) optionally, at least one comonomer of Mr1 to Mr-X comprises a functional group (FG) or linked biological substrate (L-BS).
9 more elements
-22. (canceled)
Dependencies are inferred from the claim text.