Factor XIIa Inhibitors

A compound of the formula:

• wherein R1 is aryl or heteroaryl, wherein said aryl and heteroaryl groups are optionally substituted with one to three substituents independently selected from the group consisting of hydroxyl, cyano, halo, C1-3 alkyl, O(C1-3 alkyl, NH2, CH2NH2,(C═O)NH2 or heteroaryl;
• R2 is aryl, heteroaryl,
• wherein said aryl and heteroaryl groups are optionally substituted with one to three substituents independently selected from the group consisting of hydroxyl, oxo, cyano, halo, C1-3 alkyl, C1-3 haloalkyl, O(C1-3 alkyl) and NH2;
• R3 is hydrogen, C1-3 alkyl,
• or C3-7 cycloalkyl;
• R4 is hydrogen or C1-4 alkyl;
• R5 is
• (a) hydrogen,
• (b) CH2—C3-6 cycloalkyl;
• (c) piperidinyl, which is optionally substituted with hydroxyl, oxo, cyano, halo, C1-3 alkyl, or
• (d) C1-4 alkyl which is optionally substituted with NR6R7, N+(CH3)3, NH(C═O)R6, O(C═O)R6, NR6SO2R7, NHSO2cyclopropyl or heterocyclyl, wherein said heterocyclyl is optionally substituted with R6;
• R6 is hydrogen or C1-4 alkyl, which is optionally substituted with one to three substituents independently selected from the group consisting of halo and hydroxyl;
• R7 is hydrogen or C1-3 alkyl, which is optionally substituted with one to three substituents independently selected from the group consisting of halo and hydroxyl;
• or a pharmaceutically acceptable salt thereof.