Risk stratification for ventricular arrhythmia in patients with repaired tetralogy of fallot (tof) via image-based computational simulations

A system for providing computer-generated risk stratification for ventricular arrhythmia in a patient with Tetralogy of Fallot comprising:

• an imaging modality configured for generating contrast-agent enhanced magnetic resonance image data of the patient's heart;
• a non-transitory computer readable medium configured for:
• receiving contrast-agent-enhanced magnetic resonance imaging (MRI) data of the patient's heart, wherein the patient's heart includes at least one congenital heart defect comprising Tetralogy of Fallot;
• constructing a three-dimensional computer model of at least right and left ventricles of said patient's heart using said contrast-agent-enhanced MRI data and pre-defined rules to set mechanical and electrical properties of local tissue regions within said right and left ventricles, said right ventricle having an abnormal geometry;
• performing at least one simulation of electromechanical function of said patient's heart using said three-dimensional computer model;
• testing simulated electromechanical function of said patient's heart, a plurality of times, during said at least one simulation, by applying a corresponding plurality of electrical stimulations to provide a plurality of electromechanical function outcomes;
• classifying each of said plurality of electromechanical function outcomes as at least one of exhibiting normal electromechanical function or exhibiting ventricular arrhythmic electromechanical function;
• providing a risk stratification for ventricular arrhythmia in said patient based on said classified plurality of simulations, wherein said pre-defined rules comprise assigning a tissue type to said local tissues regions within said right and left ventricles;
• and
• displaying a visual representation of the three-dimensional computer model of the patient's heart wherein the visual representation comprises the electromagnetic activity of the patient's heart.