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US 2020/0255383 A1Published application
Compounds for the treatment of pain
AssigneeAlkermes, Inc.
InventorsThomas Andrew Wynn, Juan C. Alvarez, Demetri Theodore Moustakas, Markus Haeberlein, Lewis D. Pennington
Life of this patent
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Abstract
Provided herein are compounds that are useful in the treatment of pain in a subject.
Claims17
1-23. (canceled)
A compound of Formula IV:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is C1-2 alkoxy, wherein the C1-2 alkoxy is optionally substituted with 1, 2, or 3 halo substituents;
- R2 is hydrogen, C1-6 alkyl, C3-10 cycloalkyl, 4- to 12-membered heterocycloalkyl, C1-4 alkylene-CF3, C1-4 alkylene-(C3-10 cycloalkyl), C1-4 alkylene-(4- to 12-membered heterocycloalkyl), C1-6 alkenyl, C1-4 alkylene-(C6-14 aryl), C1-4 alkylene-(5- to 14-membered heteroaryl), (C3-10 cycloalkylene)-(C6-14 aryl), (C3-10 cycloalkylene)-(5- to 14-membered heteroaryl), (4- to 12-membered heterocycloalkylene)-(C6-14 aryl), or (4- to 12-membered heterocycloalkylene)-(5- to 14-membered heteroaryl);
- wherein each of the C1-6 alkyl, C3-10 cycloalkyl, 4- to 12-membered heterocycloalkyl, C1-4 alkylene, C1-6 alkenyl, C3-10 cycloalkylene, 4- to 12-membered heterocycloalkylene, C6-14 aryl, and 5- to 14-membered heteroaryl of R2 is unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of —OH, halo, C1-4 alkyl, C1-4 alkoxy, —C(═O)—(C1-4 alkyl), —S(═O)—(C1-4 alkyl) and —S(═O)2—(C1-4 alkyl);
- or
- wherein the C3-10 cycloalkyl, 5- to 14-membered heteroaryl, or 4- to 12-membered heterocycloalkyl of R2 is optionally substituted with 1, 2, or 3 oxo moieties;
- and
- R3 is hydrogen, OH, halo, C1-4 alkyl, or C1-4 alkoxy.
5 more elements
Dependencies are inferred from the claim text.