Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases
AssigneesaTyr Pharma, Inc., Pangu BioPharma Limited
InventorsLeslie Ann GREENE, Kyle P. CHIANG, Fei HONG, Alain P. VASSEROT, Wing-Sze LO, Jeffry D. Watkins, Cheryl L. QUINN, John D. Mendlein
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Abstract
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Claims14
1-125. (canceled)
A therapeutic composition, comprising an isolated aminoacyl-tRNA synthetase (AARS) polypeptide that is at least 80%, 85%, 90%, 95%, 98%, or 100% identical to a sequence in any of Table(s) 1-9, wherein the polypeptide has a solubility of at least about 5 mg/mL, and wherein the composition has a purity of at least about 95% on a protein basis and less than about 10 EU endotoxin/mg protein.
An isolated aminoacyl-tRNA synthetase (AARS) polypeptide that is at least 80%, 85%, 90%, 95%, 98%, or 100% identical to an amino acid sequence set forth in any of Table(s) 1-9.
Dependencies are inferred from the claim text.