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US 2020/0225234 A1Published application
Method for Diagnosis of Bile Duct Cancer Using Methionyl-tRNA Synthetase in Bile Duct Cell
AssigneeOncotag Diagnostics Co., Ltd.
InventorsSunghoon Kim, Nam Hoon Kwon, Dong Ki Lee, Beom Jin Lim, Sung Ill Jang
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Abstract
The present invention relates to a method for diagnosis of bile duct cancer, using methionyl-tRNA synthetase (MRS) in bile duct cells of a latent patient.
Claims23
A method for treating a bile duct cancer in a latent patient, the method comprising the steps of:
- obtaining a sample from a latent patient;
- measuring the expression level of a methionyl-tRNA synthetase (MRS) protein in the sample;
- comparing the measured protein expression level of the latent patient with that of a control;
- diagnosing the patient with a bile duct cancer when the protein expression level of the patient is increased in comparison with that of the control;
- and
- treating the diagnosed patient by conducting at least one of a chemotherapy, a surgery, and a radiation therapy.
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A method for improving sensitivity and specificity in cytodiagnosis or biopsy for a bile duct cancer, the method comprising the steps of:
- (a) measuring the expression level of a methionyl-tRNA synthetase protein in a bile duct sample collected from a latent patient;
- and
- (b) determining that the patient is a bile duct cancer patient if the expression level of the methionyl-tRNA synthetase protein is increased in step (a).
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Dependencies are inferred from the claim text.