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US 2020/0225215 A1Published application
Screening method for selected amino-lipid-containing compositions
AssigneeArbutus Biopharma Corporation
InventorsMarco A. Ciufolini, Thomas D. Madden, Michael J. Hope, Barbara Mui, Antonin de Fougerolles, Tatiana Novobrantseva, Anna Borodovsky, Akin Akinc, Mark Tracy, Pieter Rutter Cullis
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Abstract
The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-dimethylaminomethyl-[1-3]-dioxolane by screening for an effect of the agent on the liver of a model subject.
Claims19
A method of evaluating a composition that includes a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane comprising:
- providing a composition that includes a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane;
- administering the composition to a test animal;
- and
- determining the effect of the composition on the expression of a target gene expressed in the liver of the animal,
- thereby evaluating the composition.
2 more elements
Dependencies are inferred from the claim text.